Entyvio (J3380) HCPCS Code: 2026 Medicare Units & IV Rules

Last Updated: September 12, 2026

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Billing J3380 for Entyvio (vedolizumab) requires accurate IV infusion coding and precise 1mg unit conversions to avoid Medicare denials.

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Billing Units for Entyvio (J3380)

The HCPCS definition for J3380 is "Injection, vedolizumab, 1 mg".

A standard IV dose is 300 mg. Because the code represents 1 mg increments, you must bill exactly 300 units.

DrugCodeAdministered DosageBilling Units
EntyvioJ3380300 mg300

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Medical Necessity & ICD-10 Codes

Entyvio is primarily approved for inflammatory bowel diseases. Ensure your claim includes:

  • K50.90 - Crohn's disease, unspecified, without complications
  • K51.90 - Ulcerative colitis, unspecified, without complications

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Administration Coding

Entyvio is an intravenous infusion typically lasting 30 minutes. Bill CPT code 96365 (Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour).

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