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Entyvio (J3380) HCPCS Code: 2026 Medicare Units & IV Rules

Last Updated: September 12, 2026

Billing J3380 ↗ for Entyvio (vedolizumab) requires accurate IV infusion coding and precise 1mg unit conversions to avoid Medicare denials.

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Billing Units for Entyvio (J3380)

The HCPCS definition for J3380 ↗ is "Injection, vedolizumab, 1 mg".

A standard IV dose is 300 mg. Because the code represents 1 mg increments, you must bill exactly 300 units.

DrugCodeAdministered DosageBilling Units
EntyvioJ3380300 mg300

Medical Necessity & ICD-10 Codes

Verify Medical Necessity

Don't risk a denial. See if your ICD-10 code is on the approved Medicare LCD list.

Entyvio is primarily approved for inflammatory bowel diseases. Ensure your claim includes:

Administration Coding

Entyvio is an intravenous infusion typically lasting 30 minutes. Bill CPT code 96365 ↗ (Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour).

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