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Ocrevus (J2350) HCPCS Code: 2026 Medicare Billing Guide

Last Updated: September 12, 2026

Ocrevus (ocrelizumab) is a breakthrough treatment for Multiple Sclerosis (MS). Billed under HCPCS code J2350 ↗, it requires complex IV infusion administration coding and strict diagnosis tracking.

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Calculating Units for Ocrevus (J2350)

The code J2350 ↗ is defined as "Injection, ocrelizumab, 1 mg".

A standard maintenance dose of Ocrevus is 600 mg, administered every 6 months. Therefore, you will bill exactly 600 units on the claim.

DrugCodeAdministered DosageBilling Units
OcrevusJ2350600 mg600

Covered Diagnoses (Medical Necessity)

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Ocrevus is FDA-approved and covered for relapsing or primary progressive forms of multiple sclerosis. Your claim must include a valid ICD-10 code such as:

IV Infusion Administration (CPT 96413)

Because Ocrevus is a complex biologic infusion, it is typically billed using chemotherapy/complex biologic administration codes rather than standard therapeutic infusion codes. You will generally bill 96413 ↗ (Chemotherapy administration, IV, up to 1 hour) and 96415 ↗ for each additional hour.

Always verify your specific payer's preference and run a dual-code NCCI check before submitting.

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